Epithelial Stem Cells and Cancer
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Nick Barker Lab
NICK BARKER LAB
Epithelial Stem Cells and Cancer
Institute of Molecular and Cell Biology (IMCB)
Agency for Science, Technology and Research (A*STAR)
Singapore
Research Interest
Our lab is interested in epithelial stem cell biology, specifically the role of these stem cells in the epithelial self-renewal and cancer of various organs such as esophagus, stomach and intestines. Through identification of epithelial cell-surface markers, state-of-the-art in vivo mouse models and in vitro models such as mouse and human-derived 3D organoids, we elucidate the role of these stem cells in various biological contexts such as development, homeostasis and cancer.
Latest Publication
AQP5: A functional gastric cancer stem cell marker in mouse and human tumors
Lim HYG, Yada S, Murakami K, Lee BTK, Sagiraju S, Phuah P, Chen TC-Y, Alvina FB, Tan SH, Kaslikar KK, Ruhazat NSB, Rajapakse MP, Murad KBA, Kancheva S, Tan LT, Mustafah S, So JBY & Barker N. (2025)
Science. https://doi.org/10.1126/science.adr2428
We are hiring!
The Barker Lab has an open position for a Research Officer. The successful candidate will help with mouse colony management and performing standard laboratory work, including mouse procedures, tissue processing and cell culture. Applicants who are passionate in research, motivated and a good team player are welcome to reach out to us.